A multi-scale constraint programming model of alternative splicing regulation
نویسندگان
چکیده
منابع مشابه
A multi-scale constraint programming model of alternative splicing regulation
Alternative splicing is a key process in post-transcriptional regulation, by which several kinds of mature RNA can be obtained from the same premessenger RNA. The resulting combinatorial complexity contributes to biological diversity, especially in the case of the human immunode ciency virus HIV-1. Using a constraint programming approach, we develop a model of the alternative splicing regulatio...
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Alternative splicing can alter genome sequence and as a consequence, many genes change to oncogenes. This event can also affect protein function and diversity. The growing number of study elucidate the pathological influence of impaired alternative splicing events on numerous disease including cancer. Here, we would like to highlight the significant role of alternative splicing in cancer biolog...
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Mechano-Regulation of Alternative Splicing
Alternative splicing contributes to the complexity of proteome by producing multiple mRNAs from a single gene. Affymetrix exon arrays and experiments in vivo or in vitro demonstrated that alternative splicing was regulated by mechanical stress. Expression of mechano-growth factor (MGF) which is the splicing isoform of insulin-like growth factor 1(IGF-1) and vascular endothelial growth factor (V...
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ژورنال
عنوان ژورنال: Theoretical Computer Science
سال: 2004
ISSN: 0304-3975
DOI: 10.1016/j.tcs.2004.03.062